Today, we are unveiling RamaX Opt, our ultra-fast sequence optimization workflow. We share results demonstrating 5-50x affinity maturation across 4 binder sequences, plus sequence liability removal – all in ~1 week.
To our knowledge, this is the fastest affinity maturation method available (outperforming even the most advanced existing AI approaches). Building on the binder discovery capabilities of RamaX, you can now improve affinity and remove sequence liabilities from initial hits within the same timeline.
Here’s a quick summary of the key results:
For us, this update solves another piece of the puzzle for end-to-end binder design. By linking DiffuseSandbox (design), RamaX Discovery (hit discovery), and RamaX Opt (optimization), you can move from design to a validated lead candidate all within weeks.
RamaX Opt is more than an optimization tool; it is a core component of our data strategy. Our fast experimental platforms are designed to generate high-quality datasets that will make future protein foundation models more accurate, versatile, and powerful.
We're excited to begin offering RamaX Opt as a workflow. Fill out the intake form, or get in touch to discuss how we can work together to fundamentally accelerate drug design!
In addition, we're actively looking for stellar computational and experimental scientists to grow our team. If you're excited about the problems we tackle, work with us by joining our team.
— The Diffuse team
We are eager to connect with you.
