Blog post published September 11, 2025

New Feature Release for DiffuseSandbox

Today, we're rolling out several major updates that have been highly requested by our community. We're excited to share these latest DiffuseSandbox features.

Click here to go to DiffuseSandbox now

What's New in DiffuseSandbox


Minibinder Design

Minibinders are a classic case study for de novo binder design, and we've added support for this popular binder format to the Sandbox. You'll notice a new computational metric, DiffuseMinibinderScore, which ranks the quality of output designs.


Therapeutically Relevant Frameworks

We now support using a set of prespecified frameworks for nanobody and scFv design that we’ve selected for their therapeutic relevance (stability, developability) and engineering relevance (in being a “universal” or “canonical” framework that can host many different types of CDRs).


Additional Features

We've also added support for selecting multi-chain epitopes and upped the max number of designs per job.

    Need greater access?

    Interested in running our full-scale design systems to generate libraries of designs? Sign up here to join the waitlist for API access, which unlocks usage of our internal, production-level pipelines.

    We're also continuously improving DiffuseSandbox based on user feedback to serve emerging needs in the protein design community. Get in touch with feature requests for the next DiffuseSandbox update!

    — The Diffuse team

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