End-to-End Binder Design with DiffuseSandbox and RamaX

We’re excited to announce that DiffuseSandbox now supports AI binder design at scale, with the option to immediately send designs for validation with RamaX.

The case for end-to-end design

In our previous release, we announced RamaX, a new experimental platform we developed to screen large binder libraries much more rapidly than with previous state-of-the-art methods. In the conversations we’ve been having about RamaX in the past few weeks, we’ve seen tremendous interest in being able to generate libraries and then screen them in the lab directly.

Today, we're closing the loop on design and validation. While we initially created DiffuseSandbox to be an easy-to-use tool for anyone to get started in computational AI protein design, it's since been expanded in scope and capability. To enable our partners to tackle challenging problems of therapeutic interest, we now offer support for scaled-up protein design and validation with a single click.

What's New in DiffuseSandbox

Design at scale

In a single job, you can now request up to 10k VHH, scFv, or minibinder designs.
Molecule ownership is wholly retained by the user.

RamaX integration

After a job completes, you’ll be able to request a quote for us to experimentally validate the designs. We can screen up to 100K binder sequences against 100 antigens in parallel with RamaX.

Interested in what we're working on? Get started on the Sandbox, explore partnership opportunities by getting in touch, or work with us by joining our team!
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— The Diffuse team